Scientific coordinator of Microbiota Lab
Assoc. prof.
room 2.02 Faculty of Pharmacy
Contact: jakub.piwowarski(at)wum.edu.pl
tel. +48 22 5720953
Publications
Research
Interactions between natural products and human and animal microbiota combined with research of novel postbiotic metabolites and examination of their biological activities.
Education
2017-2019
Post-doc fellowship, Institute of Pharmacy and Institute of Animal Nutrition, Freie Universität Berlin. Funded by Alexander von Humboldt Foundation.
13 XII 2017
Habilitation in Pharmaceutical Sciences.
Role of gut microbiota metabolites in biological activity of tannins. Faculty of Pharmacy, Medical University of Warsaw.
17 VI 2015
Doctorate in Pharmaceutical Sciences.
Thesis: Loosestrife (Lythri herba) - influence of extract, isolated ellagitannins, and their metabolites on pro-inflammatory functions of neutrophils. Degree received: Ph.D. with honors.
X 2010 - VI 2015
Ph.D. studies, Faculty of Pharmacy, Medical University of Warsaw.
X 2004- III 2010
Master studies, Pharmacy, Faculty of Pharmacy, Medical University of Warsaw. Degree received: Master of Pharmacy.
Scientific experience
V 2017 - VI 2017
Study visit at University of Glasgow, College of Medical, Veterinary and Life Sciences, School of Medicine, Dentistry and Nursing (funded within Foundation for Polish Science START scholarship).
X 2015 - XI 2015
Institute of Pharmacy/Pharmacognosy University of Innsbruck; (funded by Austrian Agency for International Cooperation in Education and Research).
II 2014 - VIII 2014
Institute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna (funded within National Science Centre Poland ETIUDA scholarship).
II 2012 - V 2012
Institute of Pharmacy, Freie Universität Berlin; (ERASMUS International Internship).
IX 2008 - X 2008
Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, Cracow
Basic research projects
2020 - 2024
Project manager. Influence of chemical modifications of urolithin A molecule on its metabolism and biological activities in vitro. The Polish National Science Center grant PRELUDIUM BIS 2019/35/O/NZ7/00619.
2020 - 2021
Principal investigator/project manager. Gut microbiota metabolism of natural products applied in anxiety and mood disorders. Alexander von Humboldt Foundation Return Fellowship.
2019 - 2022
Project executive. Do natural products of plant origin support the therapy of urinary tract infections? The Polish National Science Center grant OPUS 2018/29/B/NZ7/01873.
2017 - 2019
Principal investigator/project manager. Ellagitannin-rich natural products as agents modulating host: microbiota interactions. Alexander von Humboldt Foundation 3.3-POL-1188388-HFST-P.
2016 - 2019
Principal investigator/project manager. Examination of urolithins- bioavailable metabolites of human gut microbiota, on molecular processes responsible for inflammation silencing. Polish Ministry of Science and Higher Education grant IP2015 062274.
2016 - 2019
Project executive. Search for new compounds with anti-inflammatory activity from native plant species belonging to the Oleaceae family using in vitro and in vivo models together with identification of molecular mechanisms determining the observed activity. The Polish National Science Center grant OPUS 2015/17/B/NZ7/03086.
2015 - 2017
Project executive. The cooperation project for scientific exchange with Austria 2015-2017. Identification of interleukin-8 (IL-8) inhibitors from natural sources as potential anti-inflammatory agents for the treatment of respiratory tract diseases. Polish Ministry of Science and Higher Education (MNiSW) and Austrian Federal Ministry of Science, Research and Economy (BMWFW) in the frame of a Polish-Austrian cooperation (project no. FW25/RN1/14 of the Medical University of Warsaw and no. PL13/2015 of the Austrian Agency for International Cooperation in Education and Research, OeAD-GmbH).
2013 - 2015
Project executive. The influence of chosen ellagitannins on functions of human neutrophils in the context of prevention and treatment of oral cavity diseases. The Polish National Science Center grant 2012/07/N/NZ7/01136.
2013 - 2015
Project executive. Isolation and quantitative analysis of compounds from pharmacopoeial plant material Polygoni avicularis herba. Polish Ministry of Science and Higher Education grant 9006/IP1/2014/72.
2013 - 2014
Principal investigator/project manager. Loosestrife (Lythri herba)- influence of extract, isolated ellagitannins and their metabolites on pro-inflammatory functions of neutrophils. The Polish National Science Center ETIUDA grant 2013/08/T/NZ7/00011.
2012 - 2014
Principal investigator/project manager. Influence of gut flora-derived ellagitannins' metabolites- urolithins on pro-inflammatory activity of neutrophils in connection with cardiovascular disease. The Polish National Science Center PRELUDIUM grant 2011/03/N/NZ7/01785.
2011 - 2013
Project executive. Can extracts from Epilobium sp. inhibit proliferation of prostate cell line LNCaP by influencing histone acetyltransferase (HAT) activity? The Polish National Science Center SONATA grant 2011/01/D/NZ4/01261.
2009 - 2010
Project manager. Examination of hyaluronidase inhibition by aqueous extracts from tannin-rich plant materials as potential components of anti-haemorrhoidal plant preparations. Medical University of Warsaw student research grant FW 25/NM1/2009.
Applied research projects
2021 - 2023
Principal investigator/project manager. Synthesis of API, development of formulation, and in vivo studies of a cream containing human gut microbiota postbiotic metabolite – U228 for topical treatment of atopic dermatitis. The National Centre for Research and Development grant LIDER/31/0118/L-11/19/NCBR/2020.
2019 - 2020
Principal investigator/project manager. Preparation for external use in atopic inflammatory skin conditions Incubator of Innovation 2.0, Polish Ministry of Science and Higher Education grant FW25/FS227/ZW/CTT/DR/01/19.
2017 - 2019
Principal investigator/project manager. A preparation containing U228 with anti-inflammatory effects on the skin and mucous membranes. Incubator of Innovation+, Polish Ministry of Science and Higher Education grant FS200/FW25/1.
Scholarships and awards
21 X 2020
Gold Medal at International Warsaw Invention Show for the invention Urolithin A and its composition for external use in inflammations of various etiologies.
2019 - 2022
Scholarship of the Polish Minister of Science and Higher Education for outstanding young researchers.
2017 - 2019
Alexander von Humboldt Research Fellowship for Postdoctoral Researchers.
IX 2017
Bionorica Phytoneering Award for the achievements in the research on the bioactivity of ellagitannins and their gut microbiota metabolites awarded by Society for Medicinal Plant and Natural Product Research and Bionorica.
2016 - 2017
START Scholarship for Young Scientists, Foundation for Polish Science.
2015
Planta Medica journal award for the Most Innovative Paper published in 2014.
2013
Scholarship of the Polish Ministry of Science and Higher Education for the best Ph.D. students.
2012 - 2020
Medical University of Warsaw Rector Scientific Awards.