dr hab. Jakub Piwowarski

Jakub Piwowarski

Scientific coordinator of Microbiota Lab

Assoc. prof.

room 2.02 Faculty of Pharmacy

Contact: jakub.piwowarski(at)wum.edu.pl

tel. +48 22 5720953


Publications

ScopusORCID


Research

Interactions between natural products and human and animal microbiota combined with research of novel postbiotic metabolites and examination of their biological activities.

Education

2017-2019    
Post-doc fellowship, Institute of Pharmacy and Institute of Animal Nutrition, Freie Universität Berlin. Funded by Alexander von Humboldt Foundation.

13 XII 2017    
Habilitation in Pharmaceutical Sciences. 
Role of gut microbiota metabolites in biological activity of tannins. Faculty of Pharmacy, Medical University of Warsaw.

17 VI 2015    
Doctorate in Pharmaceutical Sciences. 
Thesis: Loosestrife (Lythri herba) - influence of extract, isolated ellagitannins, and their metabolites on pro-inflammatory functions of neutrophils. Degree received: Ph.D. with honors.

X 2010 - VI 2015     
Ph.D. studies, Faculty of Pharmacy, Medical University of Warsaw.

X 2004- III 2010        
Master studies, Pharmacy, Faculty of Pharmacy, Medical University of Warsaw. Degree received: Master of Pharmacy.

Scientific experience

V 2017 - VI 2017    
Study visit at University of Glasgow, College of Medical, Veterinary and Life Sciences, School of Medicine, Dentistry and Nursing (funded within Foundation for Polish Science START scholarship).

X 2015 - XI 2015    
Institute of Pharmacy/Pharmacognosy University of Innsbruck; (funded by Austrian Agency for International Cooperation in Education and Research).

II 2014 - VIII 2014    
Institute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna (funded within National Science Centre Poland ETIUDA scholarship).

II 2012 - V 2012    
Institute of Pharmacy, Freie Universität Berlin; (ERASMUS International Internship).

IX 2008 - X 2008    
Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, Cracow

Basic research projects

2020 - 2024    
Project manager. Influence of chemical modifications of urolithin A molecule on its metabolism and biological activities in vitro. The Polish National Science Center grant PRELUDIUM BIS 2019/35/O/NZ7/00619.

2020 - 2021    
Principal investigator/project manager. Gut microbiota metabolism of natural products applied in anxiety and mood disorders. Alexander von Humboldt Foundation Return Fellowship. 

2019 - 2022    
Project executive. Do natural products of plant origin support the therapy of urinary tract infections? The Polish National Science Center grant OPUS 2018/29/B/NZ7/01873. 

2017 - 2019    
Principal investigator/project manager. Ellagitannin-rich natural products as agents modulating host: microbiota interactions. Alexander von Humboldt Foundation 3.3-POL-1188388-HFST-P. 

2016 - 2019    
Principal investigator/project manager. Examination of urolithins- bioavailable metabolites of human gut microbiota, on molecular processes responsible for inflammation silencing. Polish Ministry of Science and Higher Education grant IP2015 062274. 

2016 - 2019    
Project executive. Search for new compounds with anti-inflammatory activity from native plant species belonging to the Oleaceae family using in vitro and in vivo models together with identification of molecular mechanisms determining the observed activity. The Polish National Science Center grant OPUS 2015/17/B/NZ7/03086. 

2015 - 2017    
Project executive. The cooperation project for scientific exchange with Austria 2015-2017. Identification of interleukin-8 (IL-8) inhibitors from natural sources as potential anti-inflammatory agents for the treatment of respiratory tract diseases. Polish Ministry of Science and Higher Education (MNiSW) and Austrian Federal Ministry of Science, Research and Economy (BMWFW) in the frame of a Polish-Austrian cooperation (project no. FW25/RN1/14 of the Medical University of Warsaw and no. PL13/2015 of the Austrian Agency for International Cooperation in Education and Research, OeAD-GmbH).

2013 - 2015    
Project executive. The influence of chosen ellagitannins on functions of human neutrophils in the context of prevention and treatment of oral cavity diseases. The Polish National Science Center grant 2012/07/N/NZ7/01136. 

2013 - 2015    
Project executive. Isolation and quantitative analysis of compounds from pharmacopoeial plant material Polygoni avicularis herba. Polish Ministry of Science and Higher Education grant 9006/IP1/2014/72. 

2013 - 2014    
Principal investigator/project manager. Loosestrife (Lythri herba)- influence of extract, isolated ellagitannins and their metabolites on pro-inflammatory functions of neutrophils. The Polish National Science Center ETIUDA grant 2013/08/T/NZ7/00011.

2012 - 2014    
Principal investigator/project manager. Influence of gut flora-derived ellagitannins' metabolites- urolithins on pro-inflammatory activity of neutrophils in connection with cardiovascular disease. The Polish National Science Center PRELUDIUM grant 2011/03/N/NZ7/01785. 

2011 - 2013    
Project executive. Can extracts from Epilobium sp. inhibit proliferation of prostate cell line LNCaP by influencing histone acetyltransferase (HAT) activity? The Polish National Science Center SONATA grant 2011/01/D/NZ4/01261. 

2009 - 2010    
Project manager. Examination of hyaluronidase inhibition by aqueous extracts from tannin-rich plant materials as potential components of anti-haemorrhoidal plant preparations. Medical University of Warsaw student research grant FW 25/NM1/2009. 

Applied research projects

2021 - 2023    
Principal investigator/project manager. Synthesis of API, development of formulation, and in vivo studies of a cream containing human gut microbiota postbiotic metabolite – U228 for topical treatment of atopic dermatitis. The National Centre for Research and Development grant LIDER/31/0118/L-11/19/NCBR/2020. 

2019 - 2020    
Principal investigator/project manager. Preparation for external use in atopic inflammatory skin conditions Incubator of Innovation 2.0, Polish Ministry of Science and Higher Education grant FW25/FS227/ZW/CTT/DR/01/19. 

2017 - 2019    
Principal investigator/project manager. A preparation containing U228 with anti-inflammatory effects on the skin and mucous membranes. Incubator of Innovation+, Polish Ministry of Science and Higher Education grant FS200/FW25/1. 

Scholarships and awards

21 X 2020     
Gold Medal at International Warsaw Invention Show for the invention Urolithin A and its composition for external use in inflammations of various etiologies.

2019 - 2022    
Scholarship of the Polish Minister of Science and Higher Education for outstanding young researchers.

2017 - 2019    
Alexander von Humboldt Research Fellowship for Postdoctoral Researchers.

IX 2017     
Bionorica Phytoneering Award for the achievements in the research on the bioactivity of ellagitannins and their gut microbiota metabolites awarded by Society for Medicinal Plant and Natural Product Research and Bionorica.

2016 - 2017    
START Scholarship for Young Scientists, Foundation for Polish Science.

2015        
Planta Medica journal award for the Most Innovative Paper published in 2014. 

2013    
Scholarship of the Polish Ministry of Science and Higher Education for the best Ph.D. students. 

2012 - 2020    
Medical University of Warsaw Rector Scientific Awards.